<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:7c05ceca-75e6-4087-947f-18d1fc02044c,g:6e1b0092-62c9-4da6-a95d-bd6ef3cf0609-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.capitalone.com/role/CoverPage" xlink:type="simple" xlink:href="cof-20201231.xsd#CoverPage"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CoverPage" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="simple" xlink:href="cof-20201231.xsd#CONSOLIDATEDSTATEMENTSOFINCOME"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_17f61b7a-e971-4963-ab2c-3827dfd3ca21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_9b5a6e61-8a53-401e-9564-e6ef4724b556" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_17f61b7a-e971-4963-ab2c-3827dfd3ca21" xlink:to="loc_us-gaap_InterestIncomeExpenseNet_9b5a6e61-8a53-401e-9564-e6ef4724b556" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_9c055eb7-7098-42f7-890d-8de6619aed71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_17f61b7a-e971-4963-ab2c-3827dfd3ca21" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_9c055eb7-7098-42f7-890d-8de6619aed71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_5c177828-3a40-4582-84ac-2ea297a0cc9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_bd44ff2b-642c-48f0-bc9a-4b55c28d5b51" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_5c177828-3a40-4582-84ac-2ea297a0cc9e" xlink:to="loc_us-gaap_NetIncomeLoss_bd44ff2b-642c-48f0-bc9a-4b55c28d5b51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_ParticipatingSecuritiesDistributedandUndistributedEarningsLossexcludingPreferredStockDividendsBasic_e95bfb15-a357-4344-b8c7-fe6f3877109a" xlink:href="cof-20201231.xsd#cof_ParticipatingSecuritiesDistributedandUndistributedEarningsLossexcludingPreferredStockDividendsBasic"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_5c177828-3a40-4582-84ac-2ea297a0cc9e" xlink:to="loc_cof_ParticipatingSecuritiesDistributedandUndistributedEarningsLossexcludingPreferredStockDividendsBasic_e95bfb15-a357-4344-b8c7-fe6f3877109a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_ce75c9fe-412d-43df-b5cf-e4f4c68e1b2a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_5c177828-3a40-4582-84ac-2ea297a0cc9e" xlink:to="loc_us-gaap_PreferredStockDividendsIncomeStatementImpact_ce75c9fe-412d-43df-b5cf-e4f4c68e1b2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_IssuanceCostForPreferredStockRedeemed_3538a00e-91ed-4ab7-85ea-f1e8fd52fb27" xlink:href="cof-20201231.xsd#cof_IssuanceCostForPreferredStockRedeemed"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_5c177828-3a40-4582-84ac-2ea297a0cc9e" xlink:to="loc_cof_IssuanceCostForPreferredStockRedeemed_3538a00e-91ed-4ab7-85ea-f1e8fd52fb27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_954623bb-1fe5-4736-b1de-2b1175f619b5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_ee28ceef-b060-48e4-b8d3-9a01d1778f20" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_954623bb-1fe5-4736-b1de-2b1175f619b5" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_ee28ceef-b060-48e4-b8d3-9a01d1778f20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_7a200202-c080-4cec-8fc6-45561930ca55" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_954623bb-1fe5-4736-b1de-2b1175f619b5" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_7a200202-c080-4cec-8fc6-45561930ca55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNet_1166d36a-8065-4b0c-833a-1ff83eb132b8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_48e86e4f-7b47-46d8-8abb-165935c25efc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_1166d36a-8065-4b0c-833a-1ff83eb132b8" xlink:to="loc_us-gaap_InterestAndDividendIncomeOperating_48e86e4f-7b47-46d8-8abb-165935c25efc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_e3025ae3-3845-4628-b653-5f22c4b3f1df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNet_1166d36a-8065-4b0c-833a-1ff83eb132b8" xlink:to="loc_us-gaap_InterestExpense_e3025ae3-3845-4628-b653-5f22c4b3f1df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeOperating_8c41023a-b873-42fa-a78d-b2df798191da" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndDividendIncomeOperating"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_f4fc75d5-3e74-41af-bede-7e87e68ae4d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndFeeIncomeLoansAndLeases"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_8c41023a-b873-42fa-a78d-b2df798191da" xlink:to="loc_us-gaap_InterestAndFeeIncomeLoansAndLeases_f4fc75d5-3e74-41af-bede-7e87e68ae4d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndDividendIncomeSecurities_67f767d6-4f9d-4b80-bfb6-d6033aa349be" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestAndDividendIncomeSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_8c41023a-b873-42fa-a78d-b2df798191da" xlink:to="loc_us-gaap_InterestAndDividendIncomeSecurities_67f767d6-4f9d-4b80-bfb6-d6033aa349be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherInterestAndDividendIncome_1451d961-9434-4215-baa0-de2d7998e593" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherInterestAndDividendIncome"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestAndDividendIncomeOperating_8c41023a-b873-42fa-a78d-b2df798191da" xlink:to="loc_us-gaap_OtherInterestAndDividendIncome_1451d961-9434-4215-baa0-de2d7998e593" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_7ccb1781-43cc-4084-9033-737260fe3440" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:to="loc_us-gaap_LaborAndRelatedExpense_7ccb1781-43cc-4084-9033-737260fe3440" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OccupancyNet_8a8e3fae-a3cb-4d0c-86e4-f3a94e7a570a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OccupancyNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:to="loc_us-gaap_OccupancyNet_8a8e3fae-a3cb-4d0c-86e4-f3a94e7a570a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketingExpense_d854755e-68aa-4c0e-a961-7b7a27d6a8dd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MarketingExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:to="loc_us-gaap_MarketingExpense_d854755e-68aa-4c0e-a961-7b7a27d6a8dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalAndContractServicesExpense_3a4c3afa-1a60-4825-8af2-cbec2f58c590" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProfessionalAndContractServicesExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:to="loc_us-gaap_ProfessionalAndContractServicesExpense_3a4c3afa-1a60-4825-8af2-cbec2f58c590" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommunicationsAndInformationTechnology_f4cf5a32-8e3d-4f64-b795-1999b42d50ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommunicationsAndInformationTechnology"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:to="loc_us-gaap_CommunicationsAndInformationTechnology_f4cf5a32-8e3d-4f64-b795-1999b42d50ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_bca9ab50-235a-4a76-abc2-9fd8e6960a06" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_bca9ab50-235a-4a76-abc2-9fd8e6960a06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoninterestExpense_8f7c5fc7-4bbc-4b9f-a213-93c551cf6c69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNoninterestExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestExpense_9ddd626d-d7b3-4279-8c8b-c51c75cf58bd" xlink:to="loc_us-gaap_OtherNoninterestExpense_8f7c5fc7-4bbc-4b9f-a213-93c551cf6c69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_87f2a22c-3d4d-4b4c-8a93-46be4b17829d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDeposits_9155cc57-8b18-4519-a5e8-b8488a95a577" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestExpenseDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_87f2a22c-3d4d-4b4c-8a93-46be4b17829d" xlink:to="loc_us-gaap_InterestExpenseDeposits_9155cc57-8b18-4519-a5e8-b8488a95a577" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_InterestExpenseSecuredDebt_0992f007-3468-4bfc-acba-e033b41163fa" xlink:href="cof-20201231.xsd#cof_InterestExpenseSecuredDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_87f2a22c-3d4d-4b4c-8a93-46be4b17829d" xlink:to="loc_cof_InterestExpenseSecuredDebt_0992f007-3468-4bfc-acba-e033b41163fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_InterestExpenseUnsecuredDebt_ee6e9bd1-e3a9-4aed-bf44-c5cc8ccc3c91" xlink:href="cof-20201231.xsd#cof_InterestExpenseUnsecuredDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_87f2a22c-3d4d-4b4c-8a93-46be4b17829d" xlink:to="loc_cof_InterestExpenseUnsecuredDebt_ee6e9bd1-e3a9-4aed-bf44-c5cc8ccc3c91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_InterestExpenseOtherBorrowings_e41b7317-d221-4f36-902e-5b54799c44c9" xlink:href="cof-20201231.xsd#cof_InterestExpenseOtherBorrowings"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpense_87f2a22c-3d4d-4b4c-8a93-46be4b17829d" xlink:to="loc_cof_InterestExpenseOtherBorrowings_e41b7317-d221-4f36-902e-5b54799c44c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2d9f25cd-2393-42cf-bea1-bbdf1de21393" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_3eac7e6a-2344-4b08-999d-5e502fe3536f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2d9f25cd-2393-42cf-bea1-bbdf1de21393" xlink:to="loc_us-gaap_InterestIncomeExpenseAfterProvisionForLoanLoss_3eac7e6a-2344-4b08-999d-5e502fe3536f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_002dc86a-a624-4d73-9062-63054f69c354" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2d9f25cd-2393-42cf-bea1-bbdf1de21393" xlink:to="loc_us-gaap_NoninterestIncome_002dc86a-a624-4d73-9062-63054f69c354" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestExpense_0cf7ff44-b5b9-4db7-93a1-e7d1ee98364d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2d9f25cd-2393-42cf-bea1-bbdf1de21393" xlink:to="loc_us-gaap_NoninterestExpense_0cf7ff44-b5b9-4db7-93a1-e7d1ee98364d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_3ce030f5-b5f8-41d2-ba29-a30bac321c71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_0287b891-1ee1-4610-aea1-559e474d1a9f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_3ce030f5-b5f8-41d2-ba29-a30bac321c71" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_0287b891-1ee1-4610-aea1-559e474d1a9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_7e60134f-9f84-4541-8329-4842bb459b77" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperations_3ce030f5-b5f8-41d2-ba29-a30bac321c71" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_7e60134f-9f84-4541-8329-4842bb459b77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncome_9aceee16-e070-4afa-b205-53ff13c59c60" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncome"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_ServiceChargesandOtherCustomerRelatedFees_ea20c316-e562-4ba9-a4d5-546b0bc092cf" xlink:href="cof-20201231.xsd#cof_ServiceChargesandOtherCustomerRelatedFees"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_9aceee16-e070-4afa-b205-53ff13c59c60" xlink:to="loc_cof_ServiceChargesandOtherCustomerRelatedFees_ea20c316-e562-4ba9-a4d5-546b0bc092cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_InterchangeFeesNet_0010bf41-364a-468d-a049-9c7dbfb261e5" xlink:href="cof-20201231.xsd#cof_InterchangeFeesNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_9aceee16-e070-4afa-b205-53ff13c59c60" xlink:to="loc_cof_InterchangeFeesNet_0010bf41-364a-468d-a049-9c7dbfb261e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestIncomeOther_f3e989c0-19ab-418c-b88e-df696e83ce86" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestIncomeOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_9aceee16-e070-4afa-b205-53ff13c59c60" xlink:to="loc_us-gaap_NoninterestIncomeOther_f3e989c0-19ab-418c-b88e-df696e83ce86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_202d7419-1f84-4018-8245-5fac73ca6814" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtAndEquitySecuritiesGainLoss"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NoninterestIncome_9aceee16-e070-4afa-b205-53ff13c59c60" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_202d7419-1f84-4018-8245-5fac73ca6814" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_55693bb4-76da-4d1a-afdb-8ce7caf76bea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_09c3a660-c13a-4231-ab8d-216f95073467" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_55693bb4-76da-4d1a-afdb-8ce7caf76bea" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_09c3a660-c13a-4231-ab8d-216f95073467" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_668ab132-074c-454a-9961-27686c3c56a9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_55693bb4-76da-4d1a-afdb-8ce7caf76bea" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_668ab132-074c-454a-9961-27686c3c56a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_e097548a-7674-4bb8-8916-ea934ee45361" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_e370392a-359b-4047-8877-0ff0718782e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_e097548a-7674-4bb8-8916-ea934ee45361" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_e370392a-359b-4047-8877-0ff0718782e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_eeac3ee2-c1ba-40b4-b20d-93a579d8926b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_e097548a-7674-4bb8-8916-ea934ee45361" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_eeac3ee2-c1ba-40b4-b20d-93a579d8926b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="cof-20201231.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_f7c0e4e7-a000-418b-ba7e-ffd971f9e0fc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_ac3c1f1e-94bb-46d2-b9c5-6bcb279f4ee4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_f7c0e4e7-a000-418b-ba7e-ffd971f9e0fc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_ac3c1f1e-94bb-46d2-b9c5-6bcb279f4ee4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_ee9f60d7-c8e3-4c5a-aa29-2648d84fe0cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_f7c0e4e7-a000-418b-ba7e-ffd971f9e0fc" xlink:to="loc_us-gaap_NetIncomeLoss_ee9f60d7-c8e3-4c5a-aa29-2648d84fe0cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d0a163a1-c787-4156-a8b0-a2489a0ad523" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_9284d51f-f18d-4146-b9e4-aea3ce4d4506" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d0a163a1-c787-4156-a8b0-a2489a0ad523" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_9284d51f-f18d-4146-b9e4-aea3ce4d4506" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentNetOfTaxPortionAttributableToParent_3d91314c-369c-4baf-a480-9f9e386faf20" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d0a163a1-c787-4156-a8b0-a2489a0ad523" xlink:to="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentNetOfTaxPortionAttributableToParent_3d91314c-369c-4baf-a480-9f9e386faf20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_bfbdb34e-72e4-4944-979c-1366d9951053" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d0a163a1-c787-4156-a8b0-a2489a0ad523" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_bfbdb34e-72e4-4944-979c-1366d9951053" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_d1078633-c91c-45f5-af36-1ae11e3ea613" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d0a163a1-c787-4156-a8b0-a2489a0ad523" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_d1078633-c91c-45f5-af36-1ae11e3ea613" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeOtherNetOfTaxAttributableToParent_997d4feb-9bc4-4ad8-a2e5-10da7456cbad" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeOtherNetOfTaxAttributableToParent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d0a163a1-c787-4156-a8b0-a2489a0ad523" xlink:to="loc_cof_OtherComprehensiveIncomeOtherNetOfTaxAttributableToParent_997d4feb-9bc4-4ad8-a2e5-10da7456cbad" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="cof-20201231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_7454b32e-7ac3-4fcb-a4ec-4a9d5d69ec19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsAndFederalFundsSold"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndDueFromBanks_1e074ccf-8539-422d-95c0-b2b4fec359b8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndDueFromBanks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_7454b32e-7ac3-4fcb-a4ec-4a9d5d69ec19" xlink:to="loc_us-gaap_CashAndDueFromBanks_1e074ccf-8539-422d-95c0-b2b4fec359b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositsInBanks_46263cb4-6016-4cef-8595-ad65c04b52e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestBearingDepositsInBanks"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_7454b32e-7ac3-4fcb-a4ec-4a9d5d69ec19" xlink:to="loc_us-gaap_InterestBearingDepositsInBanks_46263cb4-6016-4cef-8595-ad65c04b52e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DebtExcludingSecuredDebt_b642b639-6d59-477a-82f1-76ba7aecf780" xlink:href="cof-20201231.xsd#cof_DebtExcludingSecuredDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_013c7ff6-7a55-4c9d-af2b-04f0c77b86ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_DebtExcludingSecuredDebt_b642b639-6d59-477a-82f1-76ba7aecf780" xlink:to="loc_us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_013c7ff6-7a55-4c9d-af2b-04f0c77b86ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnsecuredDebt_58b5052c-f183-4838-af2a-07d7b46dd64e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnsecuredDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_DebtExcludingSecuredDebt_b642b639-6d59-477a-82f1-76ba7aecf780" xlink:to="loc_us-gaap_UnsecuredDebt_58b5052c-f183-4838-af2a-07d7b46dd64e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherBorrowings_0854df95-d6f3-4431-9ce9-e8cf7cb6b6f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_DebtExcludingSecuredDebt_b642b639-6d59-477a-82f1-76ba7aecf780" xlink:to="loc_us-gaap_OtherBorrowings_0854df95-d6f3-4431-9ce9-e8cf7cb6b6f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_08b6de2b-8aad-4be1-8d36-67bb7addd028" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_36ea889c-5ca6-457d-8a69-053368796ba2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_08b6de2b-8aad-4be1-8d36-67bb7addd028" xlink:to="loc_us-gaap_PreferredStockValue_36ea889c-5ca6-457d-8a69-053368796ba2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_e25c3577-c284-4ccb-93cf-35c5b8d78252" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_08b6de2b-8aad-4be1-8d36-67bb7addd028" xlink:to="loc_us-gaap_CommonStockValue_e25c3577-c284-4ccb-93cf-35c5b8d78252" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_33a99051-8a05-4d59-93e6-7221610508af" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_08b6de2b-8aad-4be1-8d36-67bb7addd028" xlink:to="loc_us-gaap_AdditionalPaidInCapital_33a99051-8a05-4d59-93e6-7221610508af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_67ff9003-cab4-45aa-b71a-a2e5e7ca08c8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_08b6de2b-8aad-4be1-8d36-67bb7addd028" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_67ff9003-cab4-45aa-b71a-a2e5e7ca08c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_757364db-9874-42a9-a0e4-bfc9ee2b5e9e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_08b6de2b-8aad-4be1-8d36-67bb7addd028" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_757364db-9874-42a9-a0e4-bfc9ee2b5e9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_f2a50ff5-26cf-49b1-a5bf-cb490a0eec6b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_08b6de2b-8aad-4be1-8d36-67bb7addd028" xlink:to="loc_us-gaap_TreasuryStockCommonValue_f2a50ff5-26cf-49b1-a5bf-cb490a0eec6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_efdbad1e-b83c-4911-b427-754b6cfbeb52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_41480585-1800-4140-a74a-5dcddeed1b00" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_efdbad1e-b83c-4911-b427-754b6cfbeb52" xlink:to="loc_us-gaap_NotesReceivableGross_41480585-1800-4140-a74a-5dcddeed1b00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_f6bda976-dfed-45ad-8f86-ed28908111a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableNet_efdbad1e-b83c-4911-b427-754b6cfbeb52" xlink:to="loc_us-gaap_FinancingReceivableAllowanceForCreditLosses_f6bda976-dfed-45ad-8f86-ed28908111a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_cd07a4ba-23e0-4ed7-b8e7-d3baada4b9f8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Deposits"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoninterestBearingDepositLiabilities_498e460a-362b-483f-8e8c-9e606f8f95f4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NoninterestBearingDepositLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cd07a4ba-23e0-4ed7-b8e7-d3baada4b9f8" xlink:to="loc_us-gaap_NoninterestBearingDepositLiabilities_498e460a-362b-483f-8e8c-9e606f8f95f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestBearingDepositLiabilities_0a4db125-5e6e-4732-8ad8-46226a3befb2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestBearingDepositLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Deposits_cd07a4ba-23e0-4ed7-b8e7-d3baada4b9f8" xlink:to="loc_us-gaap_InterestBearingDepositLiabilities_0a4db125-5e6e-4732-8ad8-46226a3befb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_d10b8da5-eaf2-4524-b3dc-245f95965c01" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_16d25e00-2081-4b96-9ef6-0ee1c8db2416" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_d10b8da5-eaf2-4524-b3dc-245f95965c01" xlink:to="loc_us-gaap_Liabilities_16d25e00-2081-4b96-9ef6-0ee1c8db2416" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_73ea8516-b520-494f-85a4-a07b00068217" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_d10b8da5-eaf2-4524-b3dc-245f95965c01" xlink:to="loc_us-gaap_StockholdersEquity_73ea8516-b520-494f-85a4-a07b00068217" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_3ec5a4b3-635d-452e-8a4c-44b08ca191af" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_d10b8da5-eaf2-4524-b3dc-245f95965c01" xlink:to="loc_us-gaap_CommitmentsAndContingencies_3ec5a4b3-635d-452e-8a4c-44b08ca191af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_30e6f843-05f6-46af-bd18-a1107df41853" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_e04673e4-c024-486a-b387-1540cd3d18f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30e6f843-05f6-46af-bd18-a1107df41853" xlink:to="loc_us-gaap_OtherLiabilities_e04673e4-c024-486a-b387-1540cd3d18f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrentAndNoncurrent_4c06e715-a6c9-422d-8063-d98c2aea1859" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestPayableCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30e6f843-05f6-46af-bd18-a1107df41853" xlink:to="loc_us-gaap_InterestPayableCurrentAndNoncurrent_4c06e715-a6c9-422d-8063-d98c2aea1859" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Deposits_67e20d47-2731-4cb6-8618-4daa5fc009eb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Deposits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30e6f843-05f6-46af-bd18-a1107df41853" xlink:to="loc_us-gaap_Deposits_67e20d47-2731-4cb6-8618-4daa5fc009eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DebtExcludingSecuredDebt_7d2cb945-4c39-436e-aed8-5fddce19eaa8" xlink:href="cof-20201231.xsd#cof_DebtExcludingSecuredDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30e6f843-05f6-46af-bd18-a1107df41853" xlink:to="loc_cof_DebtExcludingSecuredDebt_7d2cb945-4c39-436e-aed8-5fddce19eaa8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebt_80964481-ea93-408b-8839-06b532d418db" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuredDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30e6f843-05f6-46af-bd18-a1107df41853" xlink:to="loc_us-gaap_SecuredDebt_80964481-ea93-408b-8839-06b532d418db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5e394022-691f-4197-9f14-6aa27cc15daa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5e394022-691f-4197-9f14-6aa27cc15daa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_849e41d0-fcbe-4326-aed7-7f8a124cb0ed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_849e41d0-fcbe-4326-aed7-7f8a124cb0ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_45c6dfc9-934c-4da4-be83-ecb16626a86f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_45c6dfc9-934c-4da4-be83-ecb16626a86f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_f4a9481a-a246-4475-bb3d-66e5fa865a27" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_Goodwill_f4a9481a-a246-4475-bb3d-66e5fa865a27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssets_a0ba0752-7430-45d2-97d0-c5c3f88b272a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssets"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_OtherAssets_a0ba0752-7430-45d2-97d0-c5c3f88b272a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_808bc9de-aeb9-4483-9a4d-d2c867fa2e37" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsAndFederalFundsSold"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_CashCashEquivalentsAndFederalFundsSold_808bc9de-aeb9-4483-9a4d-d2c867fa2e37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_10f503d6-0c4e-4e4c-bff3-77c5dcd9ef26" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_10f503d6-0c4e-4e4c-bff3-77c5dcd9ef26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivable_fde291dd-406f-49ce-8d5c-0d0adc5d6eb0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestReceivable"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_InterestReceivable_fde291dd-406f-49ce-8d5c-0d0adc5d6eb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableNet_8f6e5442-a429-4d3f-9a3a-df6521f0738d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableNet"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_5ef65833-cacd-42d9-85cc-f73c2c20c870" xlink:to="loc_us-gaap_NotesReceivableNet_8f6e5442-a429-4d3f-9a3a-df6521f0738d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="cof-20201231.xsd#CONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="cof-20201231.xsd#CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITY" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITYParenthetical" xlink:type="simple" xlink:href="cof-20201231.xsd#CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITYParenthetical"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSTOCKHOLDERSEQUITYParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="cof-20201231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_0c0c1070-5e08-49d9-914d-7d9c381b7fc7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_0c0c1070-5e08-49d9-914d-7d9c381b7fc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_fbcbb12c-e22c-4227-884d-102ab108d2e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_fbcbb12c-e22c-4227-884d-102ab108d2e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_107c95d0-4b7b-4d29-89fb-37bbedcd420a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_107c95d0-4b7b-4d29-89fb-37bbedcd420a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_c6d0107f-9b75-4382-a3c3-1b75e5f9004c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireHeldToMaturitySecurities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_c6d0107f-9b75-4382-a3c3-1b75e5f9004c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_bf81955a-f97e-44f2-b9bb-b524b84894ed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_bf81955a-f97e-44f2-b9bb-b524b84894ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_PaymentsForProceedsFromSaleOfFinancingReceivableHeldForInvestment_dac41e16-0432-4b19-8d89-33f1052baa54" xlink:href="cof-20201231.xsd#cof_PaymentsForProceedsFromSaleOfFinancingReceivableHeldForInvestment"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_cof_PaymentsForProceedsFromSaleOfFinancingReceivableHeldForInvestment_dac41e16-0432-4b19-8d89-33f1052baa54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRecoveriesOfLoanPreviouslyChargedOff_8f16c4b7-b206-46f7-96af-9295e057dfcb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromRecoveriesOfLoanPreviouslyChargedOff"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_ProceedsFromRecoveriesOfLoanPreviouslyChargedOff_8f16c4b7-b206-46f7-96af-9295e057dfcb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_714e98f0-fd23-45e7-8143-24f67f8ee0b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_714e98f0-fd23-45e7-8143-24f67f8ee0b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_8f67c0aa-7213-4721-91b5-1893926209f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_8f67c0aa-7213-4721-91b5-1893926209f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_f1d2b99d-fbd6-4d07-8b4a-7dd2c9c38806" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_245fa235-2aaa-457f-8caf-a03c4e09848d" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_f1d2b99d-fbd6-4d07-8b4a-7dd2c9c38806" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2668e279-460b-4f78-ae47-bc81f0ba6b32" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3415db64-3bad-4106-a463-da2b43994526" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2668e279-460b-4f78-ae47-bc81f0ba6b32" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_3415db64-3bad-4106-a463-da2b43994526" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e09740e6-d296-4990-bdc5-f848d2274733" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2668e279-460b-4f78-ae47-bc81f0ba6b32" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e09740e6-d296-4990-bdc5-f848d2274733" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6a889709-5aa8-41a8-b157-d5b59c6a56ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_2668e279-460b-4f78-ae47-bc81f0ba6b32" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_6a889709-5aa8-41a8-b157-d5b59c6a56ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeposits_37165010-a7c8-442b-a799-0e7356d7a33e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInDeposits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_IncreaseDecreaseInDeposits_37165010-a7c8-442b-a799-0e7356d7a33e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_c3a50e0a-4879-496f-bdca-c4276ea0ee31" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSecuredDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_c3a50e0a-4879-496f-bdca-c4276ea0ee31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSecuredDebt_ed6beeb8-a66c-49ad-814e-9fb28d4c2153" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RepaymentsOfSecuredDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_RepaymentsOfSecuredDebt_ed6beeb8-a66c-49ad-814e-9fb28d4c2153" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_ProceedsfromIssuanceofUnsecuredDebtandLongTermFHLBAdvancesNetofIssuanceCost_03a508d9-0e9d-4c70-b0f6-c4e5cb079661" xlink:href="cof-20201231.xsd#cof_ProceedsfromIssuanceofUnsecuredDebtandLongTermFHLBAdvancesNetofIssuanceCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_cof_ProceedsfromIssuanceofUnsecuredDebtandLongTermFHLBAdvancesNetofIssuanceCost_03a508d9-0e9d-4c70-b0f6-c4e5cb079661" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_RepaymentsofUnsecuredDebtandLongTermFHLBAdvances_910aad77-faf8-4aea-99fb-d7594050b65b" xlink:href="cof-20201231.xsd#cof_RepaymentsofUnsecuredDebtandLongTermFHLBAdvances"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_cof_RepaymentsofUnsecuredDebtandLongTermFHLBAdvances_910aad77-faf8-4aea-99fb-d7594050b65b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfOtherDebt_d56fc0b2-c330-4afe-9e60-b4e336c6f450" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfOtherDebt"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfOtherDebt_d56fc0b2-c330-4afe-9e60-b4e336c6f450" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_5f8593bb-6e82-4ac4-b018-7d395d16b713" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_5f8593bb-6e82-4ac4-b018-7d395d16b713" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_81954312-f4f6-48fa-800c-a478f99d09aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_81954312-f4f6-48fa-800c-a478f99d09aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_31cea8b1-f96c-405d-bd30-0e726a9876b0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_31cea8b1-f96c-405d-bd30-0e726a9876b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_08976907-0d22-498d-a8fb-0491d766724d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_08976907-0d22-498d-a8fb-0491d766724d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_PaymentsForRedemptionOfPreferredStock_2ef6131a-2118-4fbb-a1fe-1a54d5b92943" xlink:href="cof-20201231.xsd#cof_PaymentsForRedemptionOfPreferredStock"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_cof_PaymentsForRedemptionOfPreferredStock_2ef6131a-2118-4fbb-a1fe-1a54d5b92943" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_52dfe4bc-823c-49ba-950a-15e624dcaf88" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_52dfe4bc-823c-49ba-950a-15e624dcaf88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_3def30aa-4ec3-4549-bc4d-aab368424bf7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e5c32e4b-7eb0-4724-98f7-ee00f3c9a17a" xlink:to="loc_us-gaap_ProceedsFromStockPlans_3def30aa-4ec3-4549-bc4d-aab368424bf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_16bd0255-f444-4810-aa7d-c9e3f461430b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_NetIncomeLoss_16bd0255-f444-4810-aa7d-c9e3f461430b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanLossesExpensed_21886921-5630-4336-bf2f-878db3896fe4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProvisionForLoanLossesExpensed"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_ProvisionForLoanLossesExpensed_21886921-5630-4336-bf2f-878db3896fe4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_9c0ba0b2-cb40-4da7-96f9-0f2403b60eff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_DepreciationAndAmortization_9c0ba0b2-cb40-4da7-96f9-0f2403b60eff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_e5416981-d6da-43f4-aa76-a06c13aa6891" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_e5416981-d6da-43f4-aa76-a06c13aa6891" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_07ea795d-6f90-411e-956a-e980fed196b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtAndEquitySecuritiesGainLoss"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_DebtAndEquitySecuritiesGainLoss_07ea795d-6f90-411e-956a-e980fed196b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSalesOfLoansNet_573b5ff3-4de5-4a0a-bfc3-aa439355c73a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GainLossOnSalesOfLoansNet"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_GainLossOnSalesOfLoansNet_573b5ff3-4de5-4a0a-bfc3-aa439355c73a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_004afbbb-0cb7-4356-a48f-afca6a839054" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_ShareBasedCompensation_004afbbb-0cb7-4356-a48f-afca6a839054" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_6e23c221-9595-4c7b-a149-571836156998" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_6e23c221-9595-4c7b-a149-571836156998" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForOriginationAndPurchasesOfLoansHeldForSale_06285863-11ff-44b4-b684-f5db3d9bc3ab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PaymentsForOriginationAndPurchasesOfLoansHeldForSale"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_PaymentsForOriginationAndPurchasesOfLoansHeldForSale_06285863-11ff-44b4-b684-f5db3d9bc3ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndCollectionOfLoansHeldforsale_ddd2dcb6-f105-4d51-a0b8-4898bea0d93c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ProceedsFromSaleAndCollectionOfLoansHeldforsale"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_ProceedsFromSaleAndCollectionOfLoansHeldforsale_ddd2dcb6-f105-4d51-a0b8-4898bea0d93c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_fd9a61ff-98e0-4069-8777-1e3083309244" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_fd9a61ff-98e0-4069-8777-1e3083309244" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_848890ed-2b46-4f46-8ae8-1b24a21e92b6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_848890ed-2b46-4f46-8ae8-1b24a21e92b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInterestPayableNet_852fe5cb-a5d0-4c93-9cfa-21c78961a693" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInInterestPayableNet"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_IncreaseDecreaseInInterestPayableNet_852fe5cb-a5d0-4c93-9cfa-21c78961a693" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_1aba42c4-f608-42e3-92af-5546c4a173c0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_1aba42c4-f608-42e3-92af-5546c4a173c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_4b931da1-5795-4fbd-af64-3868a0c89792" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2818c7f9-ff79-4d30-841a-3b2be235f1df" xlink:to="loc_us-gaap_CashProvidedByUsedInOperatingActivitiesDiscontinuedOperations_4b931da1-5795-4fbd-af64-3868a0c89792" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesSegmentsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPoliciesSegmentsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesSegmentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesLoansandAllowanceforCreditLossesDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPoliciesLoansandAllowanceforCreditLossesDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesLoansandAllowanceforCreditLossesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesUsefulLivesforPremisesandEquipmentDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPoliciesUsefulLivesforPremisesandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesUsefulLivesforPremisesandEquipmentDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesRevenueRecognitionDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPoliciesRevenueRecognitionDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesRevenueRecognitionDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesArrangementsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPoliciesArrangementsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesArrangementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesNewlyAdoptedAccountingStandardsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#SummaryofSignificantAccountingPoliciesNewlyAdoptedAccountingStandardsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/SummaryofSignificantAccountingPoliciesNewlyAdoptedAccountingStandardsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/InvestmentSecurities" xlink:type="simple" xlink:href="cof-20201231.xsd#InvestmentSecurities"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/InvestmentSecurities" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/InvestmentSecuritiesTables" xlink:type="simple" xlink:href="cof-20201231.xsd#InvestmentSecuritiesTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/InvestmentSecuritiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/InvestmentSecuritiesAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#InvestmentSecuritiesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/InvestmentSecuritiesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/InvestmentSecuritiesInvestmentAvailableforSaleDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#InvestmentSecuritiesInvestmentAvailableforSaleDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/InvestmentSecuritiesInvestmentAvailableforSaleDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/InvestmentSecuritiesSecuritiesinGrossUnrealizedLossPositionDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#InvestmentSecuritiesSecuritiesinGrossUnrealizedLossPositionDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/InvestmentSecuritiesSecuritiesinGrossUnrealizedLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_46ec1be7-f49f-4b7f-b574-27d2220e0f24" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_a8319471-10a9-4da3-9816-c3a21de64cde" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_46ec1be7-f49f-4b7f-b574-27d2220e0f24" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_a8319471-10a9-4da3-9816-c3a21de64cde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_bbb14e6e-58ac-42cd-b609-44e1edc7e5d0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_46ec1be7-f49f-4b7f-b574-27d2220e0f24" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_bbb14e6e-58ac-42cd-b609-44e1edc7e5d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_ecae4392-e327-4f9b-b100-bd39c06ff1b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_61d27dfb-1a28-45fc-bf30-c38eb0ed0258" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_ecae4392-e327-4f9b-b100-bd39c06ff1b4" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_61d27dfb-1a28-45fc-bf30-c38eb0ed0258" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_46aece80-68e5-4aac-af2d-22805cee0b92" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_ecae4392-e327-4f9b-b100-bd39c06ff1b4" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_46aece80-68e5-4aac-af2d-22805cee0b92" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/InvestmentSecuritiesContractualMaturitiesandWeightedAverageYieldsofSecuritiesDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#InvestmentSecuritiesContractualMaturitiesandWeightedAverageYieldsofSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/InvestmentSecuritiesContractualMaturitiesandWeightedAverageYieldsofSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_0bd1a709-5498-4e92-a07d-1d422af41cc8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_f5b1c541-6838-45ba-bf6d-ebb4400ef802" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_0bd1a709-5498-4e92-a07d-1d422af41cc8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsAmortizedCostBasis_f5b1c541-6838-45ba-bf6d-ebb4400ef802" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_d48bedb6-e30a-47de-a38a-5ab44d815b76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_0bd1a709-5498-4e92-a07d-1d422af41cc8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveAmortizedCostBasis_d48bedb6-e30a-47de-a38a-5ab44d815b76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_f0ad3067-7840-47ed-819c-ee79682e841b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_0bd1a709-5498-4e92-a07d-1d422af41cc8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenAmortizedCostBasis_f0ad3067-7840-47ed-819c-ee79682e841b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_f280aa1e-6f39-4d30-9bb1-4f26d20e8994" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_0bd1a709-5498-4e92-a07d-1d422af41cc8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenAmortizedCostBasis_f280aa1e-6f39-4d30-9bb1-4f26d20e8994" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_d23de538-d995-4f7a-b5a9-1043b9ce8f35" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_4e8979ab-1cfc-4c13-8fd1-99ae01d2bf2e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_d23de538-d995-4f7a-b5a9-1043b9ce8f35" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_4e8979ab-1cfc-4c13-8fd1-99ae01d2bf2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_2d7456bd-0857-45ce-b4cd-34d5a5ecb7b1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_d23de538-d995-4f7a-b5a9-1043b9ce8f35" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_2d7456bd-0857-45ce-b4cd-34d5a5ecb7b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_0a49230d-9a7b-4d3d-8948-a6a284dff196" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_d23de538-d995-4f7a-b5a9-1043b9ce8f35" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_0a49230d-9a7b-4d3d-8948-a6a284dff196" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_c3122578-cf75-40d0-8aff-cc6ad582b1e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_d23de538-d995-4f7a-b5a9-1043b9ce8f35" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_c3122578-cf75-40d0-8aff-cc6ad582b1e4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/InvestmentSecuritiesRealizedGainsandLossesonSecuritiesDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#InvestmentSecuritiesRealizedGainsandLossesonSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/InvestmentSecuritiesRealizedGainsandLossesonSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLossExcludingOtherThanTemporaryImpairment_dd169880-96dd-4152-a379-0fd941542bf2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLossExcludingOtherThanTemporaryImpairment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_9bf421f9-add5-4d8f-9f06-09be5f4fa8ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGain"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLossExcludingOtherThanTemporaryImpairment_dd169880-96dd-4152-a379-0fd941542bf2" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGain_9bf421f9-add5-4d8f-9f06-09be5f4fa8ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLossExcludingOtherThanTemporaryImpairment_ffd4ab00-bd29-484a-882b-507e077098c9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedLossExcludingOtherThanTemporaryImpairment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLossExcludingOtherThanTemporaryImpairment_dd169880-96dd-4152-a379-0fd941542bf2" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleRealizedLossExcludingOtherThanTemporaryImpairment_ffd4ab00-bd29-484a-882b-507e077098c9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/Loans" xlink:type="simple" xlink:href="cof-20201231.xsd#Loans"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/Loans" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansTables" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansLoanPortfolioCompositionandAgingAnalysisDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansLoanPortfolioCompositionandAgingAnalysisDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansLoanPortfolioCompositionandAgingAnalysisDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/Loans90DayDelinquentLoansAccruingInterestandNonperformingLoansDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#Loans90DayDelinquentLoansAccruingInterestandNonperformingLoansDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/Loans90DayDelinquentLoansAccruingInterestandNonperformingLoansDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansCreditCardDelinquencyStatusDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansCreditCardDelinquencyStatusDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansCreditCardDelinquencyStatusDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansConsumerBankingPortfoliobyCreditQualityIndicatorDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansConsumerBankingPortfoliobyCreditQualityIndicatorDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansConsumerBankingPortfoliobyCreditQualityIndicatorDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NotesReceivableGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedInFiscalYearBeforeLatestFiscalYear_4827efe9-5b88-4934-bed2-281f6709a411" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableOriginatedInFiscalYearBeforeLatestFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableOriginatedInFiscalYearBeforeLatestFiscalYear_4827efe9-5b88-4934-bed2-281f6709a411" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedTwoYearsBeforeLatestFiscalYear_c3d3db4c-dc8f-406c-8773-3339fe4df10a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableOriginatedTwoYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableOriginatedTwoYearsBeforeLatestFiscalYear_c3d3db4c-dc8f-406c-8773-3339fe4df10a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRevolvingConvertedToTermLoan_b04f2250-0a44-4f8f-ad41-90812dd4644e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableRevolvingConvertedToTermLoan"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableRevolvingConvertedToTermLoan_b04f2250-0a44-4f8f-ad41-90812dd4644e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedFourYearsBeforeLatestFiscalYear_7d008a49-ce97-4230-b5ed-330d6b49b460" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableOriginatedFourYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableOriginatedFourYearsBeforeLatestFiscalYear_7d008a49-ce97-4230-b5ed-330d6b49b460" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRevolving_5e509ca9-ca31-4ce0-be54-9afe95403519" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableRevolving"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableRevolving_5e509ca9-ca31-4ce0-be54-9afe95403519" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_c64eda62-20b4-4228-9bd8-36ffef6ae99f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableOriginatedFiveOrMoreYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableOriginatedFiveOrMoreYearsBeforeLatestFiscalYear_c64eda62-20b4-4228-9bd8-36ffef6ae99f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedInCurrentFiscalYear_83cfc7a5-fc46-4f2e-a9dc-c0d0c084b085" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableOriginatedInCurrentFiscalYear"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableOriginatedInCurrentFiscalYear_83cfc7a5-fc46-4f2e-a9dc-c0d0c084b085" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableOriginatedThreeYearsBeforeLatestFiscalYear_cebd6567-54ec-4a36-9257-ff04209dc147" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancingReceivableOriginatedThreeYearsBeforeLatestFiscalYear"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NotesReceivableGross_5a351756-a53e-4ca3-8169-ac7d43f14095" xlink:to="loc_us-gaap_FinancingReceivableOriginatedThreeYearsBeforeLatestFiscalYear_cebd6567-54ec-4a36-9257-ff04209dc147" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansCommercialBankingRiskProfilebyInternalRiskRatingDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansCommercialBankingRiskProfilebyInternalRiskRatingDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansCommercialBankingRiskProfilebyInternalRiskRatingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansTroubleDebtRestructuringsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansTroubleDebtRestructuringsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansTroubleDebtRestructuringsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/LoansTDRSubsequentDefaultsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#LoansTDRSubsequentDefaultsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/LoansTDRSubsequentDefaultsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitments" xlink:type="simple" xlink:href="cof-20201231.xsd#AllowanceforCreditLossesandReserveforUnfundedLendingCommitments"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitments" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsTables" xlink:type="simple" xlink:href="cof-20201231.xsd#AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsAllowanceforLoanandLeaseLossesandReserveforUnfundedLendingCommitmentsActivityDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsAllowanceforLoanandLeaseLossesandReserveforUnfundedLendingCommitmentsActivityDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsAllowanceforLoanandLeaseLossesandReserveforUnfundedLendingCommitmentsActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsSummaryofLossSharingArrangementsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsSummaryofLossSharingArrangementsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/AllowanceforCreditLossesandReserveforUnfundedLendingCommitmentsSummaryofLossSharingArrangementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizations" xlink:type="simple" xlink:href="cof-20201231.xsd#VariableInterestEntitiesandSecuritizations"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizations" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsTables" xlink:type="simple" xlink:href="cof-20201231.xsd#VariableInterestEntitiesandSecuritizationsTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#VariableInterestEntitiesandSecuritizationsAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsCarryingAmountofConsolidatedandUnconsolidatedVIEsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#VariableInterestEntitiesandSecuritizationsCarryingAmountofConsolidatedandUnconsolidatedVIEsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsCarryingAmountofConsolidatedandUnconsolidatedVIEsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsContinuingInvolvementinSecuritizationRelatedVIEsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#VariableInterestEntitiesandSecuritizationsContinuingInvolvementinSecuritizationRelatedVIEsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/VariableInterestEntitiesandSecuritizationsContinuingInvolvementinSecuritizationRelatedVIEsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/GoodwillandIntangibleAssets" xlink:type="simple" xlink:href="cof-20201231.xsd#GoodwillandIntangibleAssets"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/GoodwillandIntangibleAssets" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/GoodwillandIntangibleAssetsTables" xlink:type="simple" xlink:href="cof-20201231.xsd#GoodwillandIntangibleAssetsTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/GoodwillandIntangibleAssetsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/GoodwillandIntangibleAssetsAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#GoodwillandIntangibleAssetsAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/GoodwillandIntangibleAssetsAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/GoodwillandIntangibleAssetsComponentsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#GoodwillandIntangibleAssetsComponentsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/GoodwillandIntangibleAssetsComponentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a7b4d515-855e-4e1b-9898-b65d45890c1c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_68e10647-9fae-4b44-8dbc-d0d7cbb88911" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a7b4d515-855e-4e1b-9898-b65d45890c1c" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_68e10647-9fae-4b44-8dbc-d0d7cbb88911" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_39f53c5c-d97d-403a-ab9e-906cd5b01932" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a7b4d515-855e-4e1b-9898-b65d45890c1c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_39f53c5c-d97d-403a-ab9e-906cd5b01932" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_IntangibleAssetsGrossIncludingGoodwill_a0490999-6bb3-4495-9af3-e8ad4274a3ac" xlink:href="cof-20201231.xsd#cof_IntangibleAssetsGrossIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_9ab6a56c-d9e6-4d15-8ed0-abd11f80e7ea" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_GoodwillGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_IntangibleAssetsGrossIncludingGoodwill_a0490999-6bb3-4495-9af3-e8ad4274a3ac" xlink:to="loc_us-gaap_GoodwillGross_9ab6a56c-d9e6-4d15-8ed0-abd11f80e7ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_d33a8e8e-9b8c-4268-9d7b-f7d1b809014e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_IntangibleAssetsGrossIncludingGoodwill_a0490999-6bb3-4495-9af3-e8ad4274a3ac" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_d33a8e8e-9b8c-4268-9d7b-f7d1b809014e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_b3852579-4e52-4029-964d-da8c98a578c3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_ee57eb5e-3b38-49db-874d-b4263118d8d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_b3852579-4e52-4029-964d-da8c98a578c3" xlink:to="loc_us-gaap_Goodwill_ee57eb5e-3b38-49db-874d-b4263118d8d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_673804f6-ee9a-4db6-b890-295abee0ac3c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_b3852579-4e52-4029-964d-da8c98a578c3" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_673804f6-ee9a-4db6-b890-295abee0ac3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingAssetAtAmortizedValue_d76584ff-c31f-4a73-9101-5c94812bab71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ServicingAssetAtAmortizedValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_MortgageServicingAssetatAmortizedCostGross_95fee470-928c-4351-88d1-81f8653e2908" xlink:href="cof-20201231.xsd#cof_MortgageServicingAssetatAmortizedCostGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ServicingAssetAtAmortizedValue_d76584ff-c31f-4a73-9101-5c94812bab71" xlink:to="loc_cof_MortgageServicingAssetatAmortizedCostGross_95fee470-928c-4351-88d1-81f8653e2908" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_ServicingAssetatAmortizedCostAccumulatedAmortization_d08b1a2c-885b-4599-a40d-a6e8ac31446e" xlink:href="cof-20201231.xsd#cof_ServicingAssetatAmortizedCostAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ServicingAssetAtAmortizedValue_d76584ff-c31f-4a73-9101-5c94812bab71" xlink:to="loc_cof_ServicingAssetatAmortizedCostAccumulatedAmortization_d08b1a2c-885b-4599-a40d-a6e8ac31446e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/GoodwillandIntangibleAssetsGoodwillBusinessSegmentsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#GoodwillandIntangibleAssetsGoodwillBusinessSegmentsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/GoodwillandIntangibleAssetsGoodwillBusinessSegmentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/GoodwillandIntangibleAssetsActualandEstimatedFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#GoodwillandIntangibleAssetsActualandEstimatedFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/GoodwillandIntangibleAssetsActualandEstimatedFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ec7580a6-8da1-4aa5-af63-3a7107627590" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearFive_68fcbf6e-8459-4e55-81b2-495c6731943c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ec7580a6-8da1-4aa5-af63-3a7107627590" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearFive_68fcbf6e-8459-4e55-81b2-495c6731943c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingAfterYearFive_caf0229f-a2ec-49de-af7e-9dec3978ce21" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingAfterYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ec7580a6-8da1-4aa5-af63-3a7107627590" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingAfterYearFive_caf0229f-a2ec-49de-af7e-9dec3978ce21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearTwo_416090ac-3f58-4e3d-b553-8e3f98937176" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ec7580a6-8da1-4aa5-af63-3a7107627590" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearTwo_416090ac-3f58-4e3d-b553-8e3f98937176" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextRollingTwelveMonths_856db620-73bf-4e34-84f5-ebb67c54f912" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextRollingTwelveMonths"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ec7580a6-8da1-4aa5-af63-3a7107627590" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextRollingTwelveMonths_856db620-73bf-4e34-84f5-ebb67c54f912" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearFour_748863c4-4982-404d-ac11-29595798ee30" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ec7580a6-8da1-4aa5-af63-3a7107627590" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearFour_748863c4-4982-404d-ac11-29595798ee30" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearThree_18c8764b-8773-46ac-8d21-93d4d005e106" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ec7580a6-8da1-4aa5-af63-3a7107627590" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRollingYearThree_18c8764b-8773-46ac-8d21-93d4d005e106" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/PremisesEquipmentandLeases" xlink:type="simple" xlink:href="cof-20201231.xsd#PremisesEquipmentandLeases"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/PremisesEquipmentandLeases" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/PremisesEquipmentandLeasesTables" xlink:type="simple" xlink:href="cof-20201231.xsd#PremisesEquipmentandLeasesTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/PremisesEquipmentandLeasesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/PremisesEquipmentandLeasesComponentsofPremisesandEquipmentDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#PremisesEquipmentandLeasesComponentsofPremisesandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/PremisesEquipmentandLeasesComponentsofPremisesandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_015a9da9-5382-4194-9f47-b27f0baac714" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_92e4a09f-e63e-463c-8204-5d47c263c5e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_015a9da9-5382-4194-9f47-b27f0baac714" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_92e4a09f-e63e-463c-8204-5d47c263c5e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_56f69c58-d78e-4080-b8cd-d809bf92e872" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_015a9da9-5382-4194-9f47-b27f0baac714" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_56f69c58-d78e-4080-b8cd-d809bf92e872" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/PremisesEquipmentandLeasesOperatingLeasePortfolioDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#PremisesEquipmentandLeasesOperatingLeasePortfolioDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/PremisesEquipmentandLeasesOperatingLeasePortfolioDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_41d5b159-5f6b-433d-90e0-d50b4b5f18c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_881237e4-71f6-43e8-b58e-48d56b40a0c4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseExpense_41d5b159-5f6b-433d-90e0-d50b4b5f18c2" xlink:to="loc_us-gaap_OperatingLeaseCost_881237e4-71f6-43e8-b58e-48d56b40a0c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_279e33a1-eaff-47ca-9ee7-36bcf34f8446" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseExpense_41d5b159-5f6b-433d-90e0-d50b4b5f18c2" xlink:to="loc_us-gaap_VariableLeaseCost_279e33a1-eaff-47ca-9ee7-36bcf34f8446" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_558919fd-9161-43c8-891c-4592fc39f5ef" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_90205e75-4be5-4dcc-8d68-9b27f153dbfa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_558919fd-9161-43c8-891c-4592fc39f5ef" xlink:to="loc_us-gaap_OperatingLeaseExpense_90205e75-4be5-4dcc-8d68-9b27f153dbfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubleaseIncome_756fd2d0-60cd-4eea-98f6-5d93c59a6f69" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubleaseIncome"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_558919fd-9161-43c8-891c-4592fc39f5ef" xlink:to="loc_us-gaap_SubleaseIncome_756fd2d0-60cd-4eea-98f6-5d93c59a6f69" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/PremisesEquipmentandLeasesMaturitiesofOperatingLeasesandReconciliationtoLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#PremisesEquipmentandLeasesMaturitiesofOperatingLeasesandReconciliationtoLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/PremisesEquipmentandLeasesMaturitiesofOperatingLeasesandReconciliationtoLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52a4dad5-0732-4f09-b125-6f2e5ca3f5c4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_656ba4b8-75ab-47f1-887b-f1d7512fcf4c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52a4dad5-0732-4f09-b125-6f2e5ca3f5c4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_656ba4b8-75ab-47f1-887b-f1d7512fcf4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_e76f7daf-f165-4dd2-8c71-d3ddcce206a8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52a4dad5-0732-4f09-b125-6f2e5ca3f5c4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_e76f7daf-f165-4dd2-8c71-d3ddcce206a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_809a31ba-c8ad-48af-96d2-cff6352ffe23" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52a4dad5-0732-4f09-b125-6f2e5ca3f5c4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_809a31ba-c8ad-48af-96d2-cff6352ffe23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_232b2ed7-f92e-4998-b5b1-adb76f6e375b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52a4dad5-0732-4f09-b125-6f2e5ca3f5c4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_232b2ed7-f92e-4998-b5b1-adb76f6e375b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_3f3f5813-59c2-4ae2-8b05-bf64b2177785" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52a4dad5-0732-4f09-b125-6f2e5ca3f5c4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_3f3f5813-59c2-4ae2-8b05-bf64b2177785" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_2394a65c-38b5-400f-aea6-1c55f64a4cfc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_52a4dad5-0732-4f09-b125-6f2e5ca3f5c4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_2394a65c-38b5-400f-aea6-1c55f64a4cfc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/PremisesEquipmentandLeasesMaturitiesofOperatingLeasesandReconciliationtoLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="cof-20201231.xsd#PremisesEquipmentandLeasesMaturitiesofOperatingLeasesandReconciliationtoLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/PremisesEquipmentandLeasesMaturitiesofOperatingLeasesandReconciliationtoLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_cfd4390b-a4d6-43cf-8ee2-b23547f8b296" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_d2232ba2-9e42-4ba8-ab39-0ea6c559ce42" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_cfd4390b-a4d6-43cf-8ee2-b23547f8b296" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_d2232ba2-9e42-4ba8-ab39-0ea6c559ce42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_9705712f-b28f-4ac6-a862-d8734b66ab39" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_cfd4390b-a4d6-43cf-8ee2-b23547f8b296" xlink:to="loc_us-gaap_OperatingLeaseLiability_9705712f-b28f-4ac6-a862-d8734b66ab39" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/PremisesEquipmentandLeasesPremisesEquipmentandLeasesAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#PremisesEquipmentandLeasesPremisesEquipmentandLeasesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/PremisesEquipmentandLeasesPremisesEquipmentandLeasesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DepositsandBorrowings" xlink:type="simple" xlink:href="cof-20201231.xsd#DepositsandBorrowings"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DepositsandBorrowings" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DepositsandBorrowingsTables" xlink:type="simple" xlink:href="cof-20201231.xsd#DepositsandBorrowingsTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DepositsandBorrowingsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DepositsandBorrowingsDepositsandShorttermBorrowingsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DepositsandBorrowingsDepositsandShorttermBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DepositsandBorrowingsDepositsandShorttermBorrowingsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DepositsandBorrowingsLongTermDebtDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DepositsandBorrowingsLongTermDebtDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DepositsandBorrowingsLongTermDebtDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DepositsandBorrowingsMaturityProfileofBorrowingsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DepositsandBorrowingsMaturityProfileofBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DepositsandBorrowingsMaturityProfileofBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_8e93cbc0-f565-413c-97eb-88b5ca658cfb" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_6c069adc-bf67-4d1c-ac68-2d7950aa7394" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_8e93cbc0-f565-413c-97eb-88b5ca658cfb" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_6c069adc-bf67-4d1c-ac68-2d7950aa7394" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_4a5c894b-6e9f-4249-8b30-443dbb1b61b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_8e93cbc0-f565-413c-97eb-88b5ca658cfb" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_4a5c894b-6e9f-4249-8b30-443dbb1b61b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsWithContractualMaturityDates_4e97ef79-fb79-4097-aeb7-6451dfdda57c" xlink:href="cof-20201231.xsd#cof_TimeDepositsWithContractualMaturityDates"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesNextTwelveMonths_f56047d4-40a1-487f-b933-01e1c88fe815" xlink:href="cof-20201231.xsd#cof_TimeDepositMaturitiesWithContractualMaturityDatesNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsWithContractualMaturityDates_4e97ef79-fb79-4097-aeb7-6451dfdda57c" xlink:to="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesNextTwelveMonths_f56047d4-40a1-487f-b933-01e1c88fe815" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearTwo_5a9ee9fd-d386-4041-9496-ec4da9dcb9a1" xlink:href="cof-20201231.xsd#cof_TimeDepositMaturitiesWithContractualMaturityDatesYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsWithContractualMaturityDates_4e97ef79-fb79-4097-aeb7-6451dfdda57c" xlink:to="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearTwo_5a9ee9fd-d386-4041-9496-ec4da9dcb9a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearThree_71d71cc2-43e5-44fd-bf15-c77d3a471d61" xlink:href="cof-20201231.xsd#cof_TimeDepositMaturitiesWithContractualMaturityDatesYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsWithContractualMaturityDates_4e97ef79-fb79-4097-aeb7-6451dfdda57c" xlink:to="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearThree_71d71cc2-43e5-44fd-bf15-c77d3a471d61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearFour_51061251-d5ff-45cc-8439-f2304dd85629" xlink:href="cof-20201231.xsd#cof_TimeDepositMaturitiesWithContractualMaturityDatesYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsWithContractualMaturityDates_4e97ef79-fb79-4097-aeb7-6451dfdda57c" xlink:to="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearFour_51061251-d5ff-45cc-8439-f2304dd85629" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearFive_d8b7b54c-67ef-4c55-b039-2ca1ca9e2a29" xlink:href="cof-20201231.xsd#cof_TimeDepositMaturitiesWithContractualMaturityDatesYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsWithContractualMaturityDates_4e97ef79-fb79-4097-aeb7-6451dfdda57c" xlink:to="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesYearFive_d8b7b54c-67ef-4c55-b039-2ca1ca9e2a29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesAfterYearFive_ec1c9e25-f321-49c6-a4f2-68ca034d4bb3" xlink:href="cof-20201231.xsd#cof_TimeDepositMaturitiesWithContractualMaturityDatesAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsWithContractualMaturityDates_4e97ef79-fb79-4097-aeb7-6451dfdda57c" xlink:to="loc_cof_TimeDepositMaturitiesWithContractualMaturityDatesAfterYearFive_ec1c9e25-f321-49c6-a4f2-68ca034d4bb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_e36ec902-c39e-4be4-a7ec-b5874ab91bec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_23a08a71-bde9-42e1-904b-4b4eceb29457" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_e36ec902-c39e-4be4-a7ec-b5874ab91bec" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_23a08a71-bde9-42e1-904b-4b4eceb29457" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_ac8191ee-1e4d-4dc4-91b8-a814839f0719" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_e36ec902-c39e-4be4-a7ec-b5874ab91bec" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_ac8191ee-1e4d-4dc4-91b8-a814839f0719" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_68c5f33f-225f-447c-8d88-5f941d36f084" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_e36ec902-c39e-4be4-a7ec-b5874ab91bec" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_68c5f33f-225f-447c-8d88-5f941d36f084" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_6dc7ac3e-9f29-4d81-8306-12e343bef065" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_e36ec902-c39e-4be4-a7ec-b5874ab91bec" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_6dc7ac3e-9f29-4d81-8306-12e343bef065" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_15bd56ac-86d2-4f73-b753-c467ec77ea47" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_e36ec902-c39e-4be4-a7ec-b5874ab91bec" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_15bd56ac-86d2-4f73-b753-c467ec77ea47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_bb257d00-8acf-4626-890f-151ee3a73ae5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_e36ec902-c39e-4be4-a7ec-b5874ab91bec" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_bb257d00-8acf-4626-890f-151ee3a73ae5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/DepositsandBorrowingsMaturityProfileofBorrowingsDetails_1" xlink:type="simple" xlink:href="cof-20201231.xsd#DepositsandBorrowingsMaturityProfileofBorrowingsDetails_1"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DepositsandBorrowingsMaturityProfileofBorrowingsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_af8bd3fd-e402-4112-98bc-a1008e0e7a3c" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearFour_00387444-b279-4c57-9b31-316933545b53" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_af8bd3fd-e402-4112-98bc-a1008e0e7a3c" xlink:to="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearFour_00387444-b279-4c57-9b31-316933545b53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearTwo_a1afd009-d953-42a4-87c5-e8b0e4d4b4a3" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_af8bd3fd-e402-4112-98bc-a1008e0e7a3c" xlink:to="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearTwo_a1afd009-d953-42a4-87c5-e8b0e4d4b4a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesDebtLongtermandShorttermCombinedAmountMaturitiesNextTwelveMonths_4f8ad0b9-deb6-4cdb-a1c7-6f490426f3ac" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesDebtLongtermandShorttermCombinedAmountMaturitiesNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_af8bd3fd-e402-4112-98bc-a1008e0e7a3c" xlink:to="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesDebtLongtermandShorttermCombinedAmountMaturitiesNextTwelveMonths_4f8ad0b9-deb6-4cdb-a1c7-6f490426f3ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearFive_1dba06bc-d2e9-461e-892a-811452a38271" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_af8bd3fd-e402-4112-98bc-a1008e0e7a3c" xlink:to="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearFive_1dba06bc-d2e9-461e-892a-811452a38271" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesAfterYearFive_62bfb4c6-d19d-4f01-b9c0-d16102843d1b" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesAfterYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_af8bd3fd-e402-4112-98bc-a1008e0e7a3c" xlink:to="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesAfterYearFive_62bfb4c6-d19d-4f01-b9c0-d16102843d1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearThree_f1458d07-1d27-4ec8-b040-d9252614c310" xlink:href="cof-20201231.xsd#cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearThree"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandDebtLongtermandShorttermCombinedAmount_af8bd3fd-e402-4112-98bc-a1008e0e7a3c" xlink:to="loc_cof_TimeDepositsMaturitiesWithContractualMaturityDatesandLongTermDebtMaturitiesYearThree_f1458d07-1d27-4ec8-b040-d9252614c310" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivities" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivities"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivities" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesPolicies" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesPolicies"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesTables" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesDerivativeAssetsandLiabilitiesatFairValueDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesDerivativeAssetsandLiabilitiesatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesDerivativeAssetsandLiabilitiesatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_5c3390fa-d416-4f66-8892-f7b0478828e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_57a2a4fb-0294-4827-b193-43c32b1e0247" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_5c3390fa-d416-4f66-8892-f7b0478828e9" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_57a2a4fb-0294-4827-b193-43c32b1e0247" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossAssetAndRightToReclaimCashOffset_a4d9b02e-040b-43b9-915c-069c3b1fcd03" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossAssetAndRightToReclaimCashOffset"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_5c3390fa-d416-4f66-8892-f7b0478828e9" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossAssetAndRightToReclaimCashOffset_a4d9b02e-040b-43b9-915c-069c3b1fcd03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_b7e987ee-42b1-4e32-9d62-79b6bbcc178b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_431e6bcf-224b-400e-830a-042633dd84ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeAssets_b7e987ee-42b1-4e32-9d62-79b6bbcc178b" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_431e6bcf-224b-400e-830a-042633dd84ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossLiabilityAndObligationToReturnCashOffset_db07dac5-96b8-4125-8d03-fb7b68c54c3c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossLiabilityAndObligationToReturnCashOffset"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeAssets_b7e987ee-42b1-4e32-9d62-79b6bbcc178b" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossLiabilityAndObligationToReturnCashOffset_db07dac5-96b8-4125-8d03-fb7b68c54c3c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesHedgedItemsinFairValueHedgingRelationshipDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesHedgedItemsinFairValueHedgingRelationshipDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesHedgedItemsinFairValueHedgingRelationshipDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_aec8a52b-a0a2-47b4-9753-096177b6fef6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_f0a2c463-251b-4d13-b47f-12cd6bdc0651" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_aec8a52b-a0a2-47b4-9753-096177b6fef6" xlink:to="loc_us-gaap_DerivativeAssets_f0a2c463-251b-4d13-b47f-12cd6bdc0651" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueOfCollateral_cb475327-2c8a-412a-b166-4674d72fa7d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueOfCollateral"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_aec8a52b-a0a2-47b4-9753-096177b6fef6" xlink:to="loc_us-gaap_DerivativeAssetFairValueOfCollateral_cb475327-2c8a-412a-b166-4674d72fa7d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_a626081f-2bc0-4723-9419-38eb27a3b142" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_3fa9b448-de4f-4d0d-a484-0eb9f6fbcac3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeAssets_a626081f-2bc0-4723-9419-38eb27a3b142" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_3fa9b448-de4f-4d0d-a484-0eb9f6fbcac3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossLiability_e8a59537-9695-4efb-aa6e-cab341267fc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossLiability"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeAssets_a626081f-2bc0-4723-9419-38eb27a3b142" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossLiability_e8a59537-9695-4efb-aa6e-cab341267fc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetCollateralObligationToReturnCashOffset_b3d3d59e-bf0c-40ee-8677-07bd6737762e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetCollateralObligationToReturnCashOffset"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeAssets_a626081f-2bc0-4723-9419-38eb27a3b142" xlink:to="loc_us-gaap_DerivativeAssetCollateralObligationToReturnCashOffset_b3d3d59e-bf0c-40ee-8677-07bd6737762e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingLiabilitiesDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesOffsettingLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral_21ba83cb-0f87-4cf6-b6fb-ef8ea6a8708d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_715ef1cb-f118-404c-aaf3-429b4f489a91" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral_21ba83cb-0f87-4cf6-b6fb-ef8ea6a8708d" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_715ef1cb-f118-404c-aaf3-429b4f489a91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimSecurities_797fc905-e80c-48b9-b94c-758088fe895a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAmountOffsetAgainstCollateral_21ba83cb-0f87-4cf6-b6fb-ef8ea6a8708d" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseCollateralRightToReclaimSecurities_797fc905-e80c-48b9-b94c-758088fe895a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_83c4ff92-2a01-431e-9f49-8856c5fde4fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchase"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseGross_c5ec7295-85da-4506-972a-0267dfaa1487" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_83c4ff92-2a01-431e-9f49-8856c5fde4fd" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseGross_c5ec7295-85da-4506-972a-0267dfaa1487" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset_389570fa-62c0-4210-bfbf-9ad351a4f0b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_83c4ff92-2a01-431e-9f49-8856c5fde4fd" xlink:to="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseAsset_389570fa-62c0-4210-bfbf-9ad351a4f0b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_RepurchaseAgreementCollateralRightToReclaimCashOffset_6a9e4540-9807-406a-9f68-d9be919f62d1" xlink:href="cof-20201231.xsd#cof_RepurchaseAgreementCollateralRightToReclaimCashOffset"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_SecuritiesSoldUnderAgreementsToRepurchase_83c4ff92-2a01-431e-9f49-8856c5fde4fd" xlink:to="loc_cof_RepurchaseAgreementCollateralRightToReclaimCashOffset_6a9e4540-9807-406a-9f68-d9be919f62d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_eda9bb4e-fb55-4bee-8dff-b38f5075fa0a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_e5d1d241-2ee8-4b61-a1d6-687ac3fb1a25" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_eda9bb4e-fb55-4bee-8dff-b38f5075fa0a" xlink:to="loc_us-gaap_DerivativeLiabilities_e5d1d241-2ee8-4b61-a1d6-687ac3fb1a25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueOfCollateral_e79f7d5f-fd56-4afc-aff5-5e1b769bf2fe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueOfCollateral"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_eda9bb4e-fb55-4bee-8dff-b38f5075fa0a" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueOfCollateral_e79f7d5f-fd56-4afc-aff5-5e1b769bf2fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_9200ec92-a252-4c33-a31b-d97cdf4614ee" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_b83d20a5-0fbf-4aea-be52-ed681a6e1bb5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_9200ec92-a252-4c33-a31b-d97cdf4614ee" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_b83d20a5-0fbf-4aea-be52-ed681a6e1bb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_aaf923fe-15ab-42c1-b16f-2bc3b257ee8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossAsset"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_9200ec92-a252-4c33-a31b-d97cdf4614ee" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_aaf923fe-15ab-42c1-b16f-2bc3b257ee8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityCollateralRightToReclaimCashOffset_15ca0af0-0264-4903-8733-872d4a89d970" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityCollateralRightToReclaimCashOffset"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeLiabilities_9200ec92-a252-4c33-a31b-d97cdf4614ee" xlink:to="loc_us-gaap_DerivativeLiabilityCollateralRightToReclaimCashOffset_15ca0af0-0264-4903-8733-872d4a89d970" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesEffectsofFairValueandCashFlowHedgeAccountingDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesEffectsofFairValueandCashFlowHedgeAccountingDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesEffectsofFairValueandCashFlowHedgeAccountingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesGainsLossesonFreestandingDerivativesDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#DerivativeInstrumentsandHedgingActivitiesGainsLossesonFreestandingDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/DerivativeInstrumentsandHedgingActivitiesGainsLossesonFreestandingDerivativesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockholdersEquity" xlink:type="simple" xlink:href="cof-20201231.xsd#StockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="cof-20201231.xsd#StockholdersEquityTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockholdersEquityTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockholdersEquityPreferredStockOutstandingDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#StockholdersEquityPreferredStockOutstandingDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockholdersEquityPreferredStockOutstandingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockholdersEquityAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockholdersEquityReclassificationsfromAOCIDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#StockholdersEquityReclassificationsfromAOCIDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockholdersEquityReclassificationsfromAOCIDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockholdersEquityOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#StockholdersEquityOtherComprehensiveIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockholdersEquityOtherComprehensiveIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_ab8ec2c6-df85-4ce5-bcd5-1c5f611a8c58" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_e18c2aad-4545-4a60-8678-169250f8739c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_ab8ec2c6-df85-4ce5-bcd5-1c5f611a8c58" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_e18c2aad-4545-4a60-8678-169250f8739c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentBeforeTaxPortionAttributableToParent_35394049-e62c-4a87-8c9b-dbf1cd0822ca" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_ab8ec2c6-df85-4ce5-bcd5-1c5f611a8c58" xlink:to="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentBeforeTaxPortionAttributableToParent_35394049-e62c-4a87-8c9b-dbf1cd0822ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_430f4a76-77d3-4d66-a7f7-a266e9152326" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_ab8ec2c6-df85-4ce5-bcd5-1c5f611a8c58" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_430f4a76-77d3-4d66-a7f7-a266e9152326" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxPortionAttributableToParent_439045bb-ffdf-49ae-b6c2-4bd41e7532ca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_ab8ec2c6-df85-4ce5-bcd5-1c5f611a8c58" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxPortionAttributableToParent_439045bb-ffdf-49ae-b6c2-4bd41e7532ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossBeforeTaxAttributableToParent_0df7fb5e-ac23-403d-8ac0-f5562764c5f7" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossBeforeTaxAttributableToParent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_ab8ec2c6-df85-4ce5-bcd5-1c5f611a8c58" xlink:to="loc_cof_OtherComprehensiveIncomeLossBeforeTaxAttributableToParent_0df7fb5e-ac23-403d-8ac0-f5562764c5f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_f99c45b3-818a-4fa8-9245-e05fb8aa24ae" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_71bae497-da46-4b90-b0f0-43bb84b99c17" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_f99c45b3-818a-4fa8-9245-e05fb8aa24ae" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_71bae497-da46-4b90-b0f0-43bb84b99c17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_6cccc2eb-0f9f-4bb2-bd4b-7909476e33ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_f99c45b3-818a-4fa8-9245-e05fb8aa24ae" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_6cccc2eb-0f9f-4bb2-bd4b-7909476e33ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_20bffe8a-f9f1-410c-a958-f8046b27091e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_7bd65d2b-3c6c-43fe-b191-859b3bcc2ae4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_20bffe8a-f9f1-410c-a958-f8046b27091e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_7bd65d2b-3c6c-43fe-b191-859b3bcc2ae4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_925ae62d-739b-441b-a850-f2f75df38200" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_20bffe8a-f9f1-410c-a958-f8046b27091e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_925ae62d-739b-441b-a850-f2f75df38200" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_fdc26810-f8b1-4385-80b0-c4334ceeba56" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesTaxPortionAttributableToParent_d43545bb-bda2-4644-a6d7-3e5771857ba6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_fdc26810-f8b1-4385-80b0-c4334ceeba56" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesTaxPortionAttributableToParent_d43545bb-bda2-4644-a6d7-3e5771857ba6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_187d4dc8-d664-408f-b8a8-fc6b41758436" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_fdc26810-f8b1-4385-80b0-c4334ceeba56" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_187d4dc8-d664-408f-b8a8-fc6b41758436" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_14ba81c2-c96e-476d-a1a0-a7ef6bbb75f8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTranslationAdjustmentTaxPortionAttributableToParent_a3dc2a0f-248e-4f8e-bce8-ebf2a2a081f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTranslationAdjustmentTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_14ba81c2-c96e-476d-a1a0-a7ef6bbb75f8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTranslationAdjustmentTaxPortionAttributableToParent_a3dc2a0f-248e-4f8e-bce8-ebf2a2a081f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxPortionAttributableToParent_13f71329-50b2-4236-ac4b-fdfdc172e5e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_14ba81c2-c96e-476d-a1a0-a7ef6bbb75f8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentBeforeTaxPortionAttributableToParent_13f71329-50b2-4236-ac4b-fdfdc172e5e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentNetOfTaxPortionAttributableToParent_f4e920ef-aa0d-4351-88f6-653a9c66829c" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentBeforeTaxPortionAttributableToParent_247830e5-6af1-44aa-b6b8-6f82646692f8" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentNetOfTaxPortionAttributableToParent_f4e920ef-aa0d-4351-88f6-653a9c66829c" xlink:to="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentBeforeTaxPortionAttributableToParent_247830e5-6af1-44aa-b6b8-6f82646692f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentTaxPortionAttributableToParent_aa7ea57e-23d3-448d-b1f2-f38ef3bb0b67" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentNetOfTaxPortionAttributableToParent_f4e920ef-aa0d-4351-88f6-653a9c66829c" xlink:to="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentTaxPortionAttributableToParent_aa7ea57e-23d3-448d-b1f2-f38ef3bb0b67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeOtherNetOfTaxAttributableToParent_2382ad43-d31e-4e6e-9b0c-b47d8a382ba8" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeOtherNetOfTaxAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossBeforeTaxAttributableToParent_c88df37f-2116-43b8-8299-e10ba9743f9b" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossBeforeTaxAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_OtherComprehensiveIncomeOtherNetOfTaxAttributableToParent_2382ad43-d31e-4e6e-9b0c-b47d8a382ba8" xlink:to="loc_cof_OtherComprehensiveIncomeLossBeforeTaxAttributableToParent_c88df37f-2116-43b8-8299-e10ba9743f9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossOtherTaxAttributableToParent_c0c40ba4-f853-4298-8b7c-537aa1ef71ea" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossOtherTaxAttributableToParent"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_OtherComprehensiveIncomeOtherNetOfTaxAttributableToParent_2382ad43-d31e-4e6e-9b0c-b47d8a382ba8" xlink:to="loc_cof_OtherComprehensiveIncomeLossOtherTaxAttributableToParent_c0c40ba4-f853-4298-8b7c-537aa1ef71ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_c811922b-3b03-4bab-940c-f3abad27b074" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesTaxPortionAttributableToParent_2e9cdb54-5a36-4730-8756-b7e2d8a6fe5a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_c811922b-3b03-4bab-940c-f3abad27b074" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesTaxPortionAttributableToParent_2e9cdb54-5a36-4730-8756-b7e2d8a6fe5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentTaxPortionAttributableToParent_f06a0b2d-28ad-449a-9fd9-92b77addd28c" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_c811922b-3b03-4bab-940c-f3abad27b074" xlink:to="loc_cof_OtherComprehensiveIncomeLossSecuritiesTransferredToHeldToMaturityAdjustmentTaxPortionAttributableToParent_f06a0b2d-28ad-449a-9fd9-92b77addd28c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_f60d13b1-3ebb-404d-b123-aef43e171a76" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_c811922b-3b03-4bab-940c-f3abad27b074" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationTax_f60d13b1-3ebb-404d-b123-aef43e171a76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTranslationAdjustmentTaxPortionAttributableToParent_51d29473-ce22-49d7-893c-e3d238c5a120" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTranslationAdjustmentTaxPortionAttributableToParent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_c811922b-3b03-4bab-940c-f3abad27b074" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTranslationAdjustmentTaxPortionAttributableToParent_51d29473-ce22-49d7-893c-e3d238c5a120" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_OtherComprehensiveIncomeLossOtherTaxAttributableToParent_32a12d7d-0924-421d-9fc5-1dd4b3aa4096" xlink:href="cof-20201231.xsd#cof_OtherComprehensiveIncomeLossOtherTaxAttributableToParent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTaxPortionAttributableToParent1_c811922b-3b03-4bab-940c-f3abad27b074" xlink:to="loc_cof_OtherComprehensiveIncomeLossOtherTaxAttributableToParent_32a12d7d-0924-421d-9fc5-1dd4b3aa4096" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/RegulatoryandCapitalAdequacy" xlink:type="simple" xlink:href="cof-20201231.xsd#RegulatoryandCapitalAdequacy"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/RegulatoryandCapitalAdequacy" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/RegulatoryandCapitalAdequacyTables" xlink:type="simple" xlink:href="cof-20201231.xsd#RegulatoryandCapitalAdequacyTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/RegulatoryandCapitalAdequacyTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/RegulatoryandCapitalAdequacyCapitalRatiosUnderBaselIIIDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#RegulatoryandCapitalAdequacyCapitalRatiosUnderBaselIIIDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/RegulatoryandCapitalAdequacyCapitalRatiosUnderBaselIIIDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/RegulatoryandCapitalAdequacyAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#RegulatoryandCapitalAdequacyAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/RegulatoryandCapitalAdequacyAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EarningsPerCommonShare" xlink:type="simple" xlink:href="cof-20201231.xsd#EarningsPerCommonShare"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EarningsPerCommonShare" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EarningsPerCommonShareTables" xlink:type="simple" xlink:href="cof-20201231.xsd#EarningsPerCommonShareTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EarningsPerCommonShareTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EarningsPerCommonShareAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#EarningsPerCommonShareAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EarningsPerCommonShareAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EarningsPerCommonShareComputationofBasicandDilutedEarningsPerCommonShareDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#EarningsPerCommonShareComputationofBasicandDilutedEarningsPerCommonShareDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EarningsPerCommonShareComputationofBasicandDilutedEarningsPerCommonShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4e0c450f-f5b8-4fa7-b6ef-73eb5b5a27e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToContingentlyIssuableShares_24d7b94d-60dd-4e87-b1e4-8ab6abe56f64" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToContingentlyIssuableShares"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4e0c450f-f5b8-4fa7-b6ef-73eb5b5a27e4" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToContingentlyIssuableShares_24d7b94d-60dd-4e87-b1e4-8ab6abe56f64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_d21d3fdc-2aa1-4379-a7e2-5249985d4714" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4e0c450f-f5b8-4fa7-b6ef-73eb5b5a27e4" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_d21d3fdc-2aa1-4379-a7e2-5249985d4714" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_af94b25a-a0b7-4864-8dc5-df5d6f20f15f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_4e0c450f-f5b8-4fa7-b6ef-73eb5b5a27e4" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_af94b25a-a0b7-4864-8dc5-df5d6f20f15f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockBasedCompensationPlans" xlink:type="simple" xlink:href="cof-20201231.xsd#StockBasedCompensationPlans"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockBasedCompensationPlans" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockBasedCompensationPlansTables" xlink:type="simple" xlink:href="cof-20201231.xsd#StockBasedCompensationPlansTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockBasedCompensationPlansTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockBasedCompensationPlansSummaryofRestrictedStockUnitsandPerformanceShareUnitsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#StockBasedCompensationPlansSummaryofRestrictedStockUnitsandPerformanceShareUnitsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockBasedCompensationPlansSummaryofRestrictedStockUnitsandPerformanceShareUnitsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockBasedCompensationPlansSummaryofStockOptionsActivityDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#StockBasedCompensationPlansSummaryofStockOptionsActivityDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockBasedCompensationPlansSummaryofStockOptionsActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/StockBasedCompensationPlansAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#StockBasedCompensationPlansAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/StockBasedCompensationPlansAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EmployeeBenefitPlans" xlink:type="simple" xlink:href="cof-20201231.xsd#EmployeeBenefitPlans"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EmployeeBenefitPlans" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EmployeeBenefitPlansTables" xlink:type="simple" xlink:href="cof-20201231.xsd#EmployeeBenefitPlansTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EmployeeBenefitPlansTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EmployeeBenefitPlansDefinedContributionPlanNarrativeDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#EmployeeBenefitPlansDefinedContributionPlanNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EmployeeBenefitPlansDefinedContributionPlanNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/EmployeeBenefitPlansChangesinBenefitObligationandPlanAssetsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#EmployeeBenefitPlansChangesinBenefitObligationandPlanAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EmployeeBenefitPlansChangesinBenefitObligationandPlanAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_064a2edf-bc1e-49bc-a7f3-ed77260a05ed" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DefinedBenefitPlanFundedStatusOfPlan"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_6ca1f8a0-d7ef-4085-8fe8-4ea1c3ee5417" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_064a2edf-bc1e-49bc-a7f3-ed77260a05ed" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_6ca1f8a0-d7ef-4085-8fe8-4ea1c3ee5417" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_e686dd1d-9a80-496b-99e9-05017af8313e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_064a2edf-bc1e-49bc-a7f3-ed77260a05ed" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_e686dd1d-9a80-496b-99e9-05017af8313e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/EmployeeBenefitPlansFundedStatusRecognizedonBalanceSheetDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#EmployeeBenefitPlansFundedStatusRecognizedonBalanceSheetDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EmployeeBenefitPlansFundedStatusRecognizedonBalanceSheetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_2630245c-268a-4264-89f9-9a3feb24bd90" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_d5be9981-3702-4347-be96-0ff93daadc6b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_2630245c-268a-4264-89f9-9a3feb24bd90" xlink:to="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_d5be9981-3702-4347-be96-0ff93daadc6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_545683c9-f1d9-4f29-b396-fbcd88d63284" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInBalanceSheet_2630245c-268a-4264-89f9-9a3feb24bd90" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_545683c9-f1d9-4f29-b396-fbcd88d63284" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/EmployeeBenefitPlansDefinedBenefitPlanandOtherPostretirementBenefitPlansNarrativeDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#EmployeeBenefitPlansDefinedBenefitPlanandOtherPostretirementBenefitPlansNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/EmployeeBenefitPlansDefinedBenefitPlanandOtherPostretirementBenefitPlansNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/IncomeTaxes" xlink:type="simple" xlink:href="cof-20201231.xsd#IncomeTaxes"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/IncomeTaxes" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="cof-20201231.xsd#IncomeTaxesTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/IncomeTaxesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/IncomeTaxesSignificantComponentsofProvisionforIncomeTaxesAttributabletoContinuingOperationsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#IncomeTaxesSignificantComponentsofProvisionforIncomeTaxesAttributabletoContinuingOperationsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/IncomeTaxesSignificantComponentsofProvisionforIncomeTaxesAttributabletoContinuingOperationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_03ae4c02-099a-46bb-9719-9cf0fae30fdf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_66e6d5c6-e4f8-4539-819b-22ea389f6839" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_03ae4c02-099a-46bb-9719-9cf0fae30fdf" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_66e6d5c6-e4f8-4539-819b-22ea389f6839" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_cef7bd62-b1db-40e8-943d-8a342b12a9d9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_03ae4c02-099a-46bb-9719-9cf0fae30fdf" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_cef7bd62-b1db-40e8-943d-8a342b12a9d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_68d760b1-67e4-478b-905f-aa0ec8fb5539" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_03ae4c02-099a-46bb-9719-9cf0fae30fdf" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_68d760b1-67e4-478b-905f-aa0ec8fb5539" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_457f6f17-d1f5-4a15-9c53-ded0f4aa7cab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_4462798f-00e3-40a7-a67b-06bc57480cd3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_457f6f17-d1f5-4a15-9c53-ded0f4aa7cab" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_4462798f-00e3-40a7-a67b-06bc57480cd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_da6b873a-f5db-4af9-84ef-5d6f19bb0ef2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_457f6f17-d1f5-4a15-9c53-ded0f4aa7cab" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_da6b873a-f5db-4af9-84ef-5d6f19bb0ef2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_08c83875-1668-4a54-b519-e3696b41d0e5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_457f6f17-d1f5-4a15-9c53-ded0f4aa7cab" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_08c83875-1668-4a54-b519-e3696b41d0e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_b7684393-c3e1-4563-8471-7e5bee46d4d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_1ba97a7f-c90a-4b2c-a586-275df0c25c0d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_b7684393-c3e1-4563-8471-7e5bee46d4d4" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_1ba97a7f-c90a-4b2c-a586-275df0c25c0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_0b1b3eb6-6d78-40c6-8926-1009c71a69f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_b7684393-c3e1-4563-8471-7e5bee46d4d4" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_0b1b3eb6-6d78-40c6-8926-1009c71a69f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/IncomeTaxesEffectiveIncomeTaxRateDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#IncomeTaxesEffectiveIncomeTaxRateDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/IncomeTaxesEffectiveIncomeTaxRateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_84f0a476-e92a-4666-a701-39e850194926" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_84f0a476-e92a-4666-a701-39e850194926" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_c33ac20b-e6ce-4671-a1dc-d44e4b496d7e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_c33ac20b-e6ce-4671-a1dc-d44e4b496d7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_17fa72f0-ea16-4a0a-a23b-c62c8aac0f4f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_17fa72f0-ea16-4a0a-a23b-c62c8aac0f4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_27c4813a-3daf-4e2c-8cff-776a31657086" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_27c4813a-3daf-4e2c-8cff-776a31657086" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_EffectiveIncomeTaxRateReconciliationIRSMethodChangesPercent_4fb70ce3-7d8b-419b-8d4a-aa36d592ab55" xlink:href="cof-20201231.xsd#cof_EffectiveIncomeTaxRateReconciliationIRSMethodChangesPercent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_cof_EffectiveIncomeTaxRateReconciliationIRSMethodChangesPercent_4fb70ce3-7d8b-419b-8d4a-aa36d592ab55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_2da1a174-0e1e-444d-92c1-ea434b81897a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_2da1a174-0e1e-444d-92c1-ea434b81897a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_6d095b56-b4d5-4faf-88c1-35a0e43ae1ac" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_6d095b56-b4d5-4faf-88c1-35a0e43ae1ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense_418eff7b-52f5-44f4-826d-a89e742fdeeb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_ed9febe4-0464-4c0d-9272-02863c1be6ff" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpense_418eff7b-52f5-44f4-826d-a89e742fdeeb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/IncomeTaxesSignificantComponentsofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#IncomeTaxesSignificantComponentsofDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/IncomeTaxesSignificantComponentsofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_6918c2dd-d766-4e33-9b63-e73528cef8cf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsProvisionForLoanLosses_6918c2dd-d766-4e33-9b63-e73528cef8cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxAssetsRewardsPrograms_7cbf04fa-19b0-4b02-b4bb-bd01688f26c1" xlink:href="cof-20201231.xsd#cof_DeferredTaxAssetsRewardsPrograms"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_cof_DeferredTaxAssetsRewardsPrograms_7cbf04fa-19b0-4b02-b4bb-bd01688f26c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxAssetsLeaseLiabilities_efc017a7-a61f-4fc4-9860-1ae2419a3a1b" xlink:href="cof-20201231.xsd#cof_DeferredTaxAssetsLeaseLiabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_cof_DeferredTaxAssetsLeaseLiabilities_efc017a7-a61f-4fc4-9860-1ae2419a3a1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_9e7f5ec5-dcf2-4c92-96b4-4c63c62165d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_9e7f5ec5-dcf2-4c92-96b4-4c63c62165d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxAssetsOperatingLossCarryforwardsandTaxCreditCarryforward_12c2d418-c2f1-4a7b-a7a9-f3526f384f96" xlink:href="cof-20201231.xsd#cof_DeferredTaxAssetsOperatingLossCarryforwardsandTaxCreditCarryforward"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_cof_DeferredTaxAssetsOperatingLossCarryforwardsandTaxCreditCarryforward_12c2d418-c2f1-4a7b-a7a9-f3526f384f96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxAssetsPartnershipInvestments_6db01cbe-a737-408d-8db6-4cca0123e5fc" xlink:href="cof-20201231.xsd#cof_DeferredTaxAssetsPartnershipInvestments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_cof_DeferredTaxAssetsPartnershipInvestments_6db01cbe-a737-408d-8db6-4cca0123e5fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_aad3a6d5-ce92-4d5b-b469-7f44aca5ba53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_aad3a6d5-ce92-4d5b-b469-7f44aca5ba53" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_78897e5f-9c2e-42ff-bfde-8a5f7dd4ccda" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsDeferredIncome"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_78897e5f-9c2e-42ff-bfde-8a5f7dd4ccda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxAssetsSecurityandLoanValuations_e7ae1ee2-5565-4183-898e-0dd91ca379ca" xlink:href="cof-20201231.xsd#cof_DeferredTaxAssetsSecurityandLoanValuations"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_cof_DeferredTaxAssetsSecurityandLoanValuations_e7ae1ee2-5565-4183-898e-0dd91ca379ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_cf682ca4-1401-4cf3-84fc-8eb845a65583" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_8eef237f-a25f-4568-bec6-a510c7977f63" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_cf682ca4-1401-4cf3-84fc-8eb845a65583" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxLiabilitiesOriginalIssueDiscount_5f86959f-012e-4325-9188-fbdb5993d82f" xlink:href="cof-20201231.xsd#cof_DeferredTaxLiabilitiesOriginalIssueDiscount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_cof_DeferredTaxLiabilitiesOriginalIssueDiscount_5f86959f-012e-4325-9188-fbdb5993d82f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxLiabilitiesRightofUseAssets_56f8d55b-3b9f-4e7c-9bff-892830eeffca" xlink:href="cof-20201231.xsd#cof_DeferredTaxLiabilitiesRightofUseAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_cof_DeferredTaxLiabilitiesRightofUseAssets_56f8d55b-3b9f-4e7c-9bff-892830eeffca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxLiabilitiesSecurityandLoanValuations_d632a509-f10c-4de4-984d-ffce79122514" xlink:href="cof-20201231.xsd#cof_DeferredTaxLiabilitiesSecurityandLoanValuations"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_cof_DeferredTaxLiabilitiesSecurityandLoanValuations_d632a509-f10c-4de4-984d-ffce79122514" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_2731b198-eb95-4905-8a3e-70fb7d0681c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_2731b198-eb95-4905-8a3e-70fb7d0681c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxliabilitiesPartnershipInvestments_f01e3bd7-c7b0-4e34-8480-212641eaaa28" xlink:href="cof-20201231.xsd#cof_DeferredTaxliabilitiesPartnershipInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_cof_DeferredTaxliabilitiesPartnershipInvestments_f01e3bd7-c7b0-4e34-8480-212641eaaa28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_Deferredtaxliabilitiesloanfeesandexpenses_6a026865-7593-445d-b939-1f6e3c195a4c" xlink:href="cof-20201231.xsd#cof_Deferredtaxliabilitiesloanfeesandexpenses"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_cof_Deferredtaxliabilitiesloanfeesandexpenses_6a026865-7593-445d-b939-1f6e3c195a4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_DeferredTaxLiabilitiesDerivativeInstruments_c2938447-05f6-4e6d-b55d-07e02be1eb8a" xlink:href="cof-20201231.xsd#cof_DeferredTaxLiabilitiesDerivativeInstruments"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_cof_DeferredTaxLiabilitiesDerivativeInstruments_c2938447-05f6-4e6d-b55d-07e02be1eb8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesMortgageServicingRights_68b407a7-7fca-4fd1-b081-040ce576ff19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesMortgageServicingRights"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesMortgageServicingRights_68b407a7-7fca-4fd1-b081-040ce576ff19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_92d5f4b8-307e-4af1-ac91-e10dedb7d82b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_5cd45b43-ae25-455a-99f7-5b4ac91b0699" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_92d5f4b8-307e-4af1-ac91-e10dedb7d82b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_6f47a001-ad2c-4128-9a67-0df240f3e633" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_569a3946-095f-4c62-b0cb-a60a0897a333" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_6f47a001-ad2c-4128-9a67-0df240f3e633" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_569a3946-095f-4c62-b0cb-a60a0897a333" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_6cd9a3f9-59c8-45b5-8cc9-0c2a9aa344e9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_6f47a001-ad2c-4128-9a67-0df240f3e633" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_6cd9a3f9-59c8-45b5-8cc9-0c2a9aa344e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_882aff0a-6dc7-426b-a74b-6d7760a31fc7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_6de471cc-85ca-403e-aba4-1e59cceb71bc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_882aff0a-6dc7-426b-a74b-6d7760a31fc7" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_6de471cc-85ca-403e-aba4-1e59cceb71bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_325e8381-6dd6-4004-befc-b34699e7d3d3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_882aff0a-6dc7-426b-a74b-6d7760a31fc7" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_325e8381-6dd6-4004-befc-b34699e7d3d3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/IncomeTaxesReconciliationofChangeinUnrecognizedTaxBenefitsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#IncomeTaxesReconciliationofChangeinUnrecognizedTaxBenefitsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/IncomeTaxesReconciliationofChangeinUnrecognizedTaxBenefitsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/IncomeTaxesAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#IncomeTaxesAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/IncomeTaxesAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurement" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurement"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurement" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementTables" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_9b679c58-d44e-4fa5-8e03-b19083b15ab8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c6c78693-0a48-4fe6-b8fa-5c0ce0c39db8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_9b679c58-d44e-4fa5-8e03-b19083b15ab8" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_c6c78693-0a48-4fe6-b8fa-5c0ce0c39db8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansHeldForSaleFairValueDisclosure_719386d6-7b18-4281-bd85-c7af32f74f68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LoansHeldForSaleFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_9b679c58-d44e-4fa5-8e03-b19083b15ab8" xlink:to="loc_us-gaap_LoansHeldForSaleFairValueDisclosure_719386d6-7b18-4281-bd85-c7af32f74f68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_c4292eb9-4203-41f5-b3c5-5f40d98a1c78" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_9b679c58-d44e-4fa5-8e03-b19083b15ab8" xlink:to="loc_us-gaap_DerivativeAssets_c4292eb9-4203-41f5-b3c5-5f40d98a1c78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsFairValueDisclosure_031c459c-c12f-41a6-a3f7-daa80c8e6f51" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsFairValueDisclosure"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_9b679c58-d44e-4fa5-8e03-b19083b15ab8" xlink:to="loc_us-gaap_OtherAssetsFairValueDisclosure_031c459c-c12f-41a6-a3f7-daa80c8e6f51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_df6987a1-d7b9-4b75-985e-44bf28186ae0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_9b679c58-d44e-4fa5-8e03-b19083b15ab8" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_df6987a1-d7b9-4b75-985e-44bf28186ae0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementLevel3RecurringFairValueRollfowardDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementLevel3RecurringFairValueRollfowardDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementLevel3RecurringFairValueRollfowardDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementQuantitativeInformationaboutLevel3FairValueMeasurementsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementQuantitativeInformationaboutLevel3FairValueMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementQuantitativeInformationaboutLevel3FairValueMeasurementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementNonrecurringFairValueMeasurementsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementNonrecurringFairValueMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementNonrecurringFairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_40d31ea7-e341-4fa9-94d8-591178d13e1f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure_489b1af8-6732-4ec9-b9d5-846dbee6af71" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40d31ea7-e341-4fa9-94d8-591178d13e1f" xlink:to="loc_us-gaap_LoansReceivableFairValueDisclosure_489b1af8-6732-4ec9-b9d5-846dbee6af71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsFairValueDisclosure_d8e9c2f0-6ee9-4b63-967b-ea55234b726d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherAssetsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_40d31ea7-e341-4fa9-94d8-591178d13e1f" xlink:to="loc_us-gaap_OtherAssetsFairValueDisclosure_d8e9c2f0-6ee9-4b63-967b-ea55234b726d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementNonrecurringFairValueMeasurementsIncludedinEarningsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementNonrecurringFairValueMeasurementsIncludedinEarningsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementNonrecurringFairValueMeasurementsIncludedinEarningsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_cof_GainLossOnFairValueAssetsRecognizedInEarnings_3ba4c462-d10f-49ee-9139-2564c4ef1a18" xlink:href="cof-20201231.xsd#cof_GainLossOnFairValueAssetsRecognizedInEarnings"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_GainLossOnFairValueLoansHeldForInvestmentRecognizedInEarnings_515b7886-63a0-4d2f-aefe-9a6a35f3c9a5" xlink:href="cof-20201231.xsd#cof_GainLossOnFairValueLoansHeldForInvestmentRecognizedInEarnings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_GainLossOnFairValueAssetsRecognizedInEarnings_3ba4c462-d10f-49ee-9139-2564c4ef1a18" xlink:to="loc_cof_GainLossOnFairValueLoansHeldForInvestmentRecognizedInEarnings_515b7886-63a0-4d2f-aefe-9a6a35f3c9a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_cof_GainLossOnFairValueOtherAssetsRecognizedInEarnings_1e37306e-6ffa-448f-93e2-3e317cba87e7" xlink:href="cof-20201231.xsd#cof_GainLossOnFairValueOtherAssetsRecognizedInEarnings"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_cof_GainLossOnFairValueAssetsRecognizedInEarnings_3ba4c462-d10f-49ee-9139-2564c4ef1a18" xlink:to="loc_cof_GainLossOnFairValueOtherAssetsRecognizedInEarnings_1e37306e-6ffa-448f-93e2-3e317cba87e7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.capitalone.com/role/FairValueMeasurementFairValueofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#FairValueMeasurementFairValueofFinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/FairValueMeasurementFairValueofFinancialInstrumentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomers" xlink:type="simple" xlink:href="cof-20201231.xsd#BusinessSegmentsandRevenuefromContractswithCustomers"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomers" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersTables" xlink:type="simple" xlink:href="cof-20201231.xsd#BusinessSegmentsandRevenuefromContractswithCustomersTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersAdditionalInformationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#BusinessSegmentsandRevenuefromContractswithCustomersAdditionalInformationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersAdditionalInformationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersSegmentResultsandReconciliationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#BusinessSegmentsandRevenuefromContractswithCustomersSegmentResultsandReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersSegmentResultsandReconciliationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersRevenuefromContractswithCustomersDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#BusinessSegmentsandRevenuefromContractswithCustomersRevenuefromContractswithCustomersDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/BusinessSegmentsandRevenuefromContractswithCustomersRevenuefromContractswithCustomersDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthers" xlink:type="simple" xlink:href="cof-20201231.xsd#CommitmentsContingenciesGuaranteesandOthers"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthers" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersTables" xlink:type="simple" xlink:href="cof-20201231.xsd#CommitmentsContingenciesGuaranteesandOthersTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersUnfundedLendingCommitmentsContractualAmountandCarryingValueDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#CommitmentsContingenciesGuaranteesandOthersUnfundedLendingCommitmentsContractualAmountandCarryingValueDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersUnfundedLendingCommitmentsContractualAmountandCarryingValueDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersLossSharingandUKPPIDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#CommitmentsContingenciesGuaranteesandOthersLossSharingandUKPPIDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersLossSharingandUKPPIDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersLitigationDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#CommitmentsContingenciesGuaranteesandOthersLitigationDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CommitmentsContingenciesGuaranteesandOthersLitigationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnly" xlink:type="simple" xlink:href="cof-20201231.xsd#CapitalOneFinancialCorporationParentCompanyOnly"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnly" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyTables" xlink:type="simple" xlink:href="cof-20201231.xsd#CapitalOneFinancialCorporationParentCompanyOnlyTables"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyStatementsofIncomeDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#CapitalOneFinancialCorporationParentCompanyOnlyStatementsofIncomeDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyStatementsofIncomeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyBalanceSheetsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#CapitalOneFinancialCorporationParentCompanyOnlyBalanceSheetsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyBalanceSheetsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyStatementsofCashFlowsDetails" xlink:type="simple" xlink:href="cof-20201231.xsd#CapitalOneFinancialCorporationParentCompanyOnlyStatementsofCashFlowsDetails"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/CapitalOneFinancialCorporationParentCompanyOnlyStatementsofCashFlowsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.capitalone.com/role/RelatedPartyTransactions" xlink:type="simple" xlink:href="cof-20201231.xsd#RelatedPartyTransactions"/>
  <link:calculationLink xlink:role="http://www.capitalone.com/role/RelatedPartyTransactions" xlink:type="extended"/>
</link:linkbase>
